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Abstract CWL generated from Galaxy: COVID-19: SE Variation
DownloadAbstract CWL generated from Galaxy workflow file: COVID-19: MCRA
Abstract CWL Automatically generated from the Galaxy workflow file: COVID-19: Assembly
Abstract CWL generated from Galaxy workflow file: COVID-19: read pre-processing from SRA data
Evolutionary Analysis
Live Resources
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What's the point?
Wu et al. showed recombination between COVID-19 and bat coronaviruses located within the S-gene. We want to confirm this observation and provide a publicly accessible workflow for recombination detection.
In previous coronavirus outbreaks (SARS), retrospective analyses determined that adaptive substitutions might have occurred in the S-protein Zhang et al., e.g., related to ACE2 receptor ...
Analysis of S-protein polymorphism
Live Resources
usegalaxy.org usegalaxy.eu usegalaxy.org.au usegalaxy.be
What's the point?
In the previous portion of this study we found a non-synonymous polymorphism within the S-gene. In this section we are trying to interpret its possible effect.
Outline
Obtain coding sequences of S proteins from a diverse group of coronaviruses. Generate amino acid alignment to assess conservation of the polymorphic location.
Input
Downloaded CDS sequences of coronavirus ...
Analysis of variation within individual COVID-19 samples | March 20 2020
What's the point?
The absolute majority of SARS-COV-2 data is in the form of assembled genomic sequences. This is unfortunate because any variation that exists within individual samples is obliterated--converted to the most frequent base--during the assembly process. However, knowing underlying evolutionary dynamics is critical for tracing evolution of the virus as it allows identification of genomic regions under different ...
